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sage decreases outcomes of diazepam by pharmacodynamic antagonism. Insignificant/Significance Unknown. Theoretical conversation; some species of sage may perhaps bring about convulsions.

Resulting from extensive-acting metabolite, not deemed a drug of decision while in the aged; connected to falls

Assess Each and every client’s threat previous to prescribing and observe regularly for the event of such disorders

Mobile phone 999 or go to A&E if: You or some other person has taken benzodiazepines and it has symptoms like:

Paradoxical reactions may arise like hallucinations, aggressive behavior, and psychoses; dinscontinue use if reactions arise

diltiazem will raise the stage or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

Lencapavir (a average CYP3A4 inhibitor) may well raise CYP3A4 substrates initiated in just 9 months after past SC dose of lenacapavir, which can boost opportunity threat of adverse reactions of CYP3A4 substrates.

diazepam will increase the amount or impact of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Propylene glycol toxicity reported in patients dealt with with diazepam injection at doses appreciably larger than proposed when it absolutely was getting used to deal with alcohol withdrawal signs at doses >900 mg/day Propylene glycol toxicity is affiliated with an anion gap metabolic acidosis, serum hyperosmolality, and improved lactate

Diazepam is stored preferentially in a few organs, including the coronary heart. Absorption by any administered route more info and the risk of accumulation is noticeably improved from the neonate, and withdrawal of diazepam all through pregnancy and breast feeding is clinically justified.[112]

Drugs which have stage therapy associated with Each and every prescription. This restriction generally requires that particular requirements be met before acceptance to the prescription.

tazemetostat will lower the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

Observe Intently (1)diazepam will enhance the degree or outcome of finerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

fluconazole will improve the amount or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

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